1. PERSONAL:
Name/Surname : Ahmet GENC
Citizenship : Turkish
Telephone : (+90) 416 223 3800 /4180
E-Mail : ahmetgencc@gmail.com & agenc@adiyaman.edu.tr
Address : Adiyaman University, Vocational School of Health Services, Altinsehir, Adiyaman / Turkey 02040
Languages : English, Turkish
2. EDUCATION
Doctorate Degree: PhD in Biochemistry, Cukurova University, Faculty of Medicine Department of Biochemistry, Adana, Turkey (October 2005 -July 2009).
Masters’ Degree: Master of Science in Biochemistry, Cukurova University, Faculty of Medicine, Department of Biochemistry, Adana, Turkey (October 2003 – July 2005).
Bachelors’ Degree : Bachelor of Science in Biology. Cukurova University, Faculty of Arts and Sciences, Department of Biology, Adana, Turkey (September 1997 – June 2002).
3. WORK EXPERIENCE
2015-present Assoc.Prof.Dr
Adiyaman University, Vocational School of Health Services
2009- 2015 Assist. Prof. Dr.
Adiyaman University, Vocational School of Health Services
2007-2008: Performed the routine laboratory analyses at Inherited Blood Disease Diagnosis Center Unit as a biologist.
Experienced on DNA Sequencing (Beckman Coulter CEQ 8000), real-time PCR (identification of MTHFR, FV and FII polymorphisms) and detection of beta-alpha globin gene mutations with strip assay
2004-2009: Performed the routine laboratory analyses at prenatal diagnosis unit as a research assistant. Experienced on DNA Sequencing, ARMS (amplification refractory mutation system), RFLP (restriction fragment length polymorphism), VNTR (variable number of tandem repeats), SSCP (single strand conformational polymorphism).
2002-2009: Taught Biochemistry Practice Course to Medical School students.
4. RESEARCH AREAS
Genetics of alpha and beta thalassemia, and sickle cell anemia; population genetics, clinical biochemistry
5. SOME PROJECT PARTICIPATION
Worked as a research assistant or project coordinator in the projects which have been written beloved:
5.1. Alpha Thalassemia and HbH Disease, Cukurova University, Research Grant, TF2005BAP3, Researcher, 2005.
5.2. Identification of Tiopurine S-Methyl Transferase (TPMT) genotyping, Cukurova University, Research Grant, TF2007BAP32, Researcher, 2007.
5.3. Determination of Factor V Leiden mutation in Cukurova Region, Cukurova University, Research Grant, TF2007BAP33, Researcher, 2007.
5.4. Beta Thalassemia in Adiyaman, Adiyaman University, Research Grant, SHMYOBAP2010/0002, Project Coordinator, 2010.
5.5. Determination of thalassemia frequency and education in Adiyaman, Republic of Turkey Prime Ministry Southeastern Anatolia Project Regional Development Administration, Project Number:1638, Project Coordinator, 2010.
5.6. Investigate the genotoxic effect of cytogenetic and molecular level of CuO used as fungicides. Adiyaman University, Research Grant, FEFBAP/2013-0001, Researcher, 2015.
5.7. Roles of selected genetic variants in telomerase reverse transcriptase (hTERT) gene in gastric cancer. Adiyaman University, Research Grant, SYOBAP/2013-0001, Researcher, 2015.
5.8. Roles of genetic factors in the molecular pathogenesis of nonalcoholic fatty liver disease (NAFLD). Adiyaman University, Research Grant, SYOBAP/2014-0001, Researcher, 2016.
5.9. Determination of prevalence and molecular characterization of alpha-thalassemia in Adiyaman Province. Adiyaman University, Research Grant, SHMYOBAP/2014-0001, Project Coordinator, 2016.
5.10. Determination of beta globin gene haplotypes associated with beta-thalassemia. Adiyaman University, Research Grant, SHMYOBAP/2014-0002, Project Coordinator, continues.
5.11. Determination of mutations in hereditary persistence of fetal hemoglobin (HPFH) associated with beta-thalassemia. Adiyaman University, Research Grant, FEFBAP/2014-0004, Researcher, continues.
5.12.
6. THESES
A) Master thesis
Identification of abnormal hemoglobins with DNA sequencing
Ahmet Genc
B) PhD thesis
Identification of Thiopurine S-Methyl Transferase (TPMT) genotyping
Ahmet Genc
7. PUBLICATIONS
A) Research Articles
1. Zeren F, Genc A, Curuk MA. Preliminary data on preimplantation genetic diagnosis for hemoglobinopathies in Turkey. Hemoglobin, 2007;31(2): 273-7.
2. Curuk MA, Genc A, Huseynova P, Zeren F, Aksoy K. Genotypes pf alpha thalassemia and HbH disease in Cukuorva. Turkiye Klinikleri, J Pediatr Sci, 2007;3(10):17-23.
3. Curuk MA, Zeren F, Genc A, Aygun-Ozavci S, Kilinc Y, Aksoy K. Prenatal diagnosis of sickle cell anemia and beta thalassemia in Southern Turkey. Hemoglobin, 2008;32(6):525-530 (doi: 10.1080/03630260802508269).
4. Eroglu F, Genc A, Elgun G, Koltas IS. Identification of Blastocystis hominis isolates from asymptomatic and symptomatic patients by PCR. Parasitol Res, 2009 Nov;105(6):1589-92 (doi: 10.1007/s00436-009-1595-6).
5. Ozerdem D, Eroglu F, Genc A, Demirkazik M, Koltas IS. Comparison of microscopic examination, rK39, and PCR for visceral leishmaniasis diagnosis in Turkey. Parasitol Res, 2009 Dec;106(1):197-200 (doi: 10.1007/s00436-009-1650-3).
6. Genc A, Eroglu F, Koltas IS. Detection of Plasmodium vivax by nested PCR and real-time PCR. Korean J of Parasitol, 2010 Jun;48(2):99-103 (doi: 10.3347/kjp.2010.48.2.99).
7. Eroglu F, Koltas IS, Genc A. Identification of Causative Species in Cutaneous Leishmaniasis Patients Using PCR-RFLP. J Bacteriol Parasitol, 2011;2:113 (doi: 10.4172/2155-9597.1000113).
8. Genc A, Curuk MA. Two rare Hb variants in Cukurova region; Hb E-Saskatoon & Hb G-Coushatta. Turk J Hematol, 2011;28(4):323-6 (doi: 10.5152/tjh.2011.88).
9. Genc A, Gunasti S, Tuli A, Curuk M A, Uzun S. Thiopurine S-methyltransferase gene polymorphism in pemphigus vulgaris. Post Dermatol Alergol, 2012;XXIX, 1:25-9.
10. Genc A, Tastemir Korkmaz D, Buyukleyla M, Celiker M. Prevalence and molecular analysis of β-thalassemia in Adiyaman, Turkey. Hemoglobin, 2012;36(2):131-8 (doi: 10.3109/03630269.2012.658128)
11. Tug Bozdogan S, Unsal C, Erkman H, Genc A, Ozalp Yuregir O, Muslumanoglu M H, Aslan H. Nonsense β-thalassemia mutation at codon 37 (TGG>TGA), detected for the first time in three Turkish cases. Hemoglobin, 2012;36(3):283-8 (doi: 10.3109/03630269.2012.662197).
12. Genc A, Tastemir Korkmaz D, Urhan Kucuk M, Rencuzogullari E, Atakur S, Bayram S, Oncerci M, Koc T, Aslan S, Almas AM, Alici MF, Sevgiler Y, Tuncdemir A. Prevalence of beta-thalassemia trait and abnormal hemoglobins in the province of Adıyaman, Turkey. Pediatr Hematol Oncol, 2012 Oct;29(7):620-3 (doi: 10.3109/08880018.2012.713085).
13. Uysal A, Genc A, Tasyurek N, Turkyilmaz B. Prevalence of beta-thalassemia trait and abnormal hemoglobin in premarital screening in the province of Izmir, Turkey. J Pediatr Hematol Oncol, 2013 Feb;30(1):46-50 (doi: 10.3109/08880018.2012.742604).
14. Incebiyik A, Genc A, Gul Hilali N, Camuzcuoglu A, Camuzcuoglu H, Kilic A, Vural M. Prevalence of β-thalassemia trait and abnormal hemoglobins in Sanliurfa Province in southeast Turkey. Hemoglobin, 2014 Nov;38(6):402-4 (doi: 10.3109/03630269.2014.978008).
15. Bayram S, Sumbul AT, Batmacı CY, Genc A. Effect of HOTAIR rs920778 polymorphism on breast cancer susceptibility and clinicopathologic features in a Turkish population. Tumour Biol, 2015 May;36(5):3863-70 (doi:10.1007/s13277-014-3028-0).
16. Bayram S, Ulger Y, Sumbul AT, Kaya BY, Rencuzogullari A, Genc A, Sevgiler Y, Bozkurt O, Rencuzogullari E. A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study. Fam Cancer, 2015 Dec; 14(4):561-7 (doi:10.1007/s10689-015-9813-0)
17. Bayram S, Rencuzogullari E, Almas AM, Genc A.Effect of p53 Arg72Pro polymorphism on the induction of micronucleus by aflatoxin B1 in in vitro in human blood lymphocytes. Drug Chem Toxicol, 2016 Jan;39(3):331-7. (DOI:10.3109/01480545.2015.1121275)
18. Bayram S, Genc A, Buyukleyla M, Rencuzogullari E. Genotoxicity and cytotoxicity of copper oxychloride in cultured human lymphocytes using cytogenetic and molecular tests. Cytotechnology, 2016 Oct;68(5):2027-36. (doi: 10.1007/s10616-016-9943-8)
19. Bayram S, Ülger Y,Sümbül AT, Kaya BY, Genç A,Rencüzoğulları E, Dadaş E. Polymorphisms in human telomerase reverse transcritase (hTERT) gene and susceptibility to gastric cancer in a Turkish population: Hospital-based case-control study. Gene, 2016 July;585(1):84-92. (DOI:10.1016/j.gene.2016.03.030)
20. Genç A, Sevgiler Y, Bayram S, Rencüzoğulları E. The prevalence and genotypes of alpha-thalassemia in Adıyaman: two rare alpha variants. Turk J Biochem, 2016 Jan;41(6):467-72. (DOI:10.1515/tjb-2016-0149).
21. Ülger Y, Dadaş E, Yalınbaş Kaya B, Sümbül AT, Genç A, Bayram S. The analysis of lncRNA HOTAIR rs12826786 C>T polymorphism and gastric cancer susceptibility in a Turkish population: lack of any association in a hospital-based case–control study, Irish Journal of Medical Science, 2017 Nov;186(4):859-865. (DOI: 10.1007/s1184)
22. Aydın M, Arslan M, Rencüzoğulları E, Gözaydın C, Genç A, Bayram S. Investigation of XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms effects on the induction of micronucleus by Aflatoxin B1 in in vitro. Gene Reports, 2017 ;9:1-6. (DOI: 10.1016/j.genrep.2017.08.002).
23. Aydın M, Rencüzoğulları E, Bayram S, Sevgiler Y, Genç A. Alterations on high HbF levels may be associated with KLF1 gene mutations. Cellular and Molecular Biology, 2017; 63(8):51-7.
24. Aydın M, Rencüzoğulları E, Bozkurt O, Genç A, Bayram S. Investigation of genotoxic effects of doripenem using cytogenetic and molecular methods. Cellular and Molecular Biology, 2017; 6(10):14.
25. Genc A, Tastemir Korkmaz D, Bayram S, Rencuzogullari E. The Effect of Five Single Nucleotide Polymorphisms on Hb F Variation of β-Thalassemia Traits and Hematologically Normal Individuals in Southeast Turkey. Hemoglobin, 2020;pp.1-9 (DOI:10.1080/03630269.2020.1787178)
B) National Papers
1. Genc A, Curuk MA. Molecular pathology of Hemophilia A. Cukurova University Medicine Faculty, Archives, 2008;17(2):122-45 (in Turkish).
2. Genc A, Curuk MA. Molecular pathology of Hemophilia B. Cukurova University Medicine Faculty, Archives, 2008;17(2):146-58 (in Turkish).
3. Eroglu F, Genc A, Koltas IS. The genotyping of Echinococcus granulosusisolates with PCR-RFLP methods in Adana Province. Journal of Zirve University Medicine Faculty, 2016;1(1):22-5. (in Turkish)
4. Eroglu F, Genc A, Curuk MA, Koltas IS.The use of serological and molecular methods in diagnosis of foreign origin Plasmodium falciparum strains. Journal of Zirve University Medicine Faculty, 2016;1(1):32-4. (Short communication) (in Turkish)
C) PROCEEDINGS/SYMPOSIUM
International Proceedings/Symposium
1. Genc A, Zeren F, Temiz D, Curuk MA. Abnormal hemoglobins in Cukurova, two rare variants; HbE-Saskatoon & HbG-Coushatta. 31st FEBS Congress, 24-29 June 2006, Istanbul.
2. Eroglu F, Kotlas SI, Demirhindi H, Genc A, Demirkazik M, Curuk MA. Diagnosis of Leishmania infantum from smear samples taken from cutaneous leishmaniosis cases by using the PCR-RFLP method. 57th American Society of Tropical Medicine and Hygiene Annual Meeting, P2798. December 7-11, 2008, New Orleans, USA.